All medical treatments and procedures can have unintended effects/side effects. It might be difficult to fully understand what some medical terms mean and how experiencing such a complication might affect your health, especially if you are young and/or have never had to deal with health issues before. For this reason I am including a small, basic dictionary of medical complications. Not all people will experience complications, and some complications are (very) rare, but as some of these rare complications can have devastating consequence for someone's body and their life, it is vital that people understand what they are choosing to risk when they undergo cosmetic interventions (drugs, surgery). Always read all information provided to you and ask your endocrinologist or surgeon all your questions before you start taking hormones/blockers or undergoing a procedure!
You can find a lot of first-person accounts of medical transition (use of drugs and cosmetic surgeries) on YouTube, in Reddit communities, (closed) Facebook groups, and sometimes in news articles.
Blood clot
Blood can form clots during/after surgery. These can cause problems when they get stuck in an artery and prevent blood from reaching certain tissues or organs (such as in the case of a pulmonary embolism, where a blood clot blocks blood flow to a lung, or in an ischaemic stroke where a blood clot blocks bloodflow to the brain) or when they prevent blood from flowing back to the heart (such as in deep vein thrombosis). It is possible to lose a limb to a blood clot. You can have permanent brain damage from an ischaemic stroke (caused by a blood clot). It is also possible to die from a blood clot that is not treated in time.
Blood loss
Losing blood is a risk for any surgery. When too much blood is lost the patient may need to receive a blood transfusion (where blood from other people is given to the patient to replace the blood the patient lost).
Bone health
Bone development takes place throughout childhood and puberty is one of the periods of rapid bone growth and mineralisation. Sex hormones are essential for bone maturation during puberty (see
https://www.frontiersin.org/articles/10.3389/fendo.2022.967711/full). Use of puberty blockers (gonadotropin-releasing hormone (GnRH) analogues (GnRHa)) or progestins to block the body's own production of sex hormones can affect bone development and increase the risk for osteoporosis later in life (see
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9150228/). A review from 2022 states: "Results consistently indicate a negative impact of long-term puberty suppression on bone mineral density, especially at the lumbar spine, which is only partially restored after sex steroid administration." (see
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9578106/). The NY Times dedicated an article to puberty blockers used in transgenderism and shared an anecdote about a Texas teenager who had very low bone density in the lumbar spine (the lower back) after a year on puberty blockers. No scan was performed at baseline (before the treatment) so it is possible this child had a low value to begin with, but because no scan was performed before use of the blockers, they will never know. The story of another teenager was also included. This teen took drugs from age 11 to 14 and no scans were performed until the last year of treatment. This patient developed osteoporosis and experienced a compression fracture in the spine with continued back pain as a consequence of this permanent disability caused by puberty blockers (see
https://www.nytimes.com/2022/11/14/health/puberty-blockers-transgender.html).
Breast implant illness (BII)
This is a systemic complication associated with breast implants. Signs and symptoms can include joint and muscle pain, chronic fatigue, breathing problems, anxiety, depression, headaches, hairloss, memory and concentration problems. Women who have silicone gel-filled implants were more likely to be diagnosed with auto immune conditions such as Sjogren syndrome, scleroderma, or rheumatoid arthritis. Find more information here:
https://www.breastcancer.org/treatment/surgery/breast-reconstruction/types/implant-reconstruction/illness/breast-implant-illness.
Catheter
A suprapubic (SP) catheter is inserted into the bladder through a hole made into the abdomen (belly); a Foley catheter is inserted through the urethra (the tube that transports urine from your bladder to the outside of your body) and held in place in the bladder by a water-filled balloon. Depending on the type of genital surgery and whether you have complications, you may only need a catheter for a few days or in extreme cases for months at a time.
Colostomy, ileostomy, urostomy
An ostomy is surgery to create an opening (stoma) from an area inside the body to the outside. This is done when there are issues with the tissue further down so the damaged area is avoided by funelling the body fluid out of the body before the problem area.
A colostomy is an opening from the colon (large intestine) to the outside through the abdomen (belly). A colostomy bag is then attached to catch the fecal matter (poop, stool). This bag needs to be emptied/replaced several times a day to every couple of days depending on the type of bag and consistency of stool. You may need a colostomy for a shorter period of time or for the rest of your life depending on what the reasons are. A temporary colostomy may be needed after colon surgery to remove cancer, for instance. You may end up with a permanent colostomy if a certain part of the colon had to be removed or permanently rested, or if you can not undergo more surgery due to other health problems. Information on living with a colostomy:
https://www.nhs.uk/conditions/colostomy/living-with/.
An ileostomy is an opening from the small intestine to the outside through the abdomen (belly). This is performed when the colon needs to be removed of rested after surgery or treatment. A stoma bag is then attached to catch the fecal matter (poop, stool). This bag needs to be emptied/replaced. Information on ileostomy:
https://www.nhs.uk/conditions/ileostomy/.
A urostomy is performed when someone's bladder is removed or urine can't pass through the bladder and urethra (for instance due to damage to the urethra after surgery). The procedure creates a stoma for the urinary system by using a bit of intestine. Also called an 'ileal cinduit urinary diversion'. The urine is collected in a pouch on the outside of the body.
Death
Every surgery comes with the risk of death either from the anaesthesia or the procedure itself, but usually death is a very rare surgical outcome. Certain factors may increase the risk of death from the surgery, such as in emergency operations, when the patient is of an older age, or when the patient undergoes a major procedure. See
https://pubmed.ncbi.nlm.nih.gov/24021395/ for information in mortality (death) risk in various surgeries.
Death is a possible consequence of genital surgery for gender reasons, as described in a case study on an 18-year-old male who underwent vaginoplasty, who died from the results of an
E. coli infection, see
https://www.sciencedirect.com/science/article/abs/pii/S1083318816301747.
Dilating difficulties
Dilation is the process of using hard dildos to keep open the neovaginal canal/tunnel. This is required after vaginoplasty surgery to ensure the canal does not heal shut or shrink in length or width. It is possible to experience a lot of pain during dilation. A YouTuber ('Adea') who had vaginoplasty explained how he was in so much pain he was sweating and nearly passed out from dilation. Other people may experience less pain or even no pain but this might be due to nerve damage. This could result in them being rougher with their canal than is good for it, damaging the canal in the process (of dilation, or sex). It may also be impossible to dilate enough to not lose depth (length) or width because at some point you no longer have time to spend 4 hours a day on dilation and the cleanup. It may become impossible to dilate if the canal has gotten so shallow or narrow that the dilators are all too big, this can also make it hard to douche to clean out the canal. The result may be that the canal ends up with a pocket at the end that collects mucous, lube, body fluids (from sexual intercourse) and if it is not possible to douche well, this might result in infections and discomfort.
Diverticulum
Small sacs or pockets that can form in the (neo)urethra (urethral diverticulum) that fill up with urine. This may be accompanied by pain, frequent urinary tract infections, incontinence, or blood in your urine. This needs to be corrected with surgery.
A female who underwent phalloplasty genital surgery experienced a lot of complications including urethral diverticulum in her urethra. The diverticulum keeps filling and got infected so needed to be drained requiring her to wear a catheter again (see Exulansic's video 'Phalloplasty Philes: Your Own Portable Lake Lanier').
Embolism
This is when an artery is blocked by a foreign body such as a blood clot or air bubble. One cause of this is when a blood clot from the deep veins in your leg (deep vein thrombosis, DVT) breaks off and travels to another part of the body where it blocks blood flow. A pulmonary embolism is a blood clot like this that gets stuck in your lung artery where it blocks blood flow to your lungs. This is an emergency. See
https://www.nhs.uk/conditions/embolism/. One patient who had phalloplasty genital surgery experienced a host of complications including bilateral pulmonary embolism (blood clots in both her lungs, but also her legs and pelvic area, she also had a urinary tract infection that developed into a kidney infection, it was bad; see Exulansic's video 'Phalloplasty Philes: Requiem for a Peen (Gruffin)).
A female reddit user describes how she underwent phalloplasty genital surgery and ended up with bilateral (on both sides) pulmonary embolisms with the beginning signs of tissue damage, at only 24 years old. She had to stay in the hospital for three additional weeks and ended up with a relatively short phallus at 3" in length 'on a good day' but the urethra hole at the top healed over so she needs another surgery to fix that (see Exulansic's video 'Phalloplasty Philes: The No-Eyed Trouser Snake').
Erosion or fracture of erectile device/implant
Some people who have undergone phalloplasty choose to have an inflatable erectile device implanted in the neophallus to imitate an erection. These devices are developed for males with erectile dysfunction so naturally their use in a surgically-created ‘penis’ will be experimental: a neophallus does not have the same anatomy as a penis. However, a new erectile device is being developed currently (in 2023) specifically for the neophallus. With the devices developed for males it is possible for the implant to erode out of the phallus, meaning that parts of the implant put pressure on the tissues and skin to the extent they are ‘working their way out’. This will need to be corrected in a surgery to prevent the skin from being broken and the parts of the device sliding out through the open wound (with the risks of infection that come with an open wound). One reddit user who posts on the phallo subreddit has seemingly had over 25 procedures related to her phalloplasty including several replacements/fixes of her inflatable erectile device, and this was all when she was in her late teens to early/mid 20s. As of July 2023 her phallus has failed after about 5-6 years since the first surgery because of a lot of internal scarring due to use of the erectile device, so the device had to be permanently removed leaving a short, creased neophallus. She is now considering a complete redo of her phalloplasty to try again... It is also possible to instead of an inflatable erectile device choose the semi-rigid rod implant (also called malleable penile prosthesis). This is a pair of rods that are implanted into the 'shaft' of the phallus and are anchored to the pubic bone. The implant is bent upwards for sex and downwards to be 'flaccid'. The rods themselves can fracture, although this appears to be rare, see
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4811081/.
Fistula
This is when an abnormal tunnel forms between two internal organs or an internal organ and the outside of the body. A fistula usually does not heal on its own and will usually require surgery to resolve. It is possible to have multiple fistulae at the same time. If one forms between your urethra (pee tube) and the outside of your body, you will leak urine from it when you pee. This is very common in women who choose phalloplasty with urethral lengthening. The result is that they will pee from one or multiple sites aside from the tip of their phallus, spraying urine everywhere. It is also possible for a fistula to form between the rectum or colon and the neovagina. The person may then leak faeces through the neovagina and/or get infections in the neovagina because poop bacteria are getting inside the canal. They wil also have problems with foul odour.
One story of a male who had a vaginoplasty who developed a fistula resulted in a temporary loop ileostomy causing him to become suicidal (see Exulansic's video 'Vaginoplasty Volumes: Tuck Everlasting (Reddit Chronicles)').
A female reddit user who underwent metoidioplasty genital surgery four weeks prior ended up with a fistula at the base of her 'scrotum' that leaks when she pees even if she tries pushing toilet paper onto it. Another user chimes in saying she experiences the same issue having developed a fistula after the initial surgery, but in her case she also had two failed repair surgeries so now 16 months after the initial surgery she is still dealing with a fistula (see Exulansic's video 'Metoidioplasty Moments: A Fistful of Fistula').
A female TikTok user who underwent phalloplasty genital surgery seemingly developed a fistula with urine coming out from around her 'scrotum' that required additional surgery to fix (see Exulansic's video 'Phalloplasty Philes: Pissing into the Windmill').
Another story is that of Ryan James, a female who had phalloplasty surgery. She developed a fistula and had to have a colostomy as a result of the vaginectomy (removal of the vagina) as part of the phalloplasty procedure (see Exulansic's interviews with Ryan James).
Granulation
Granulation tissue is a type of new connective tissue. This can form when healing from surgery. Pink granulation tissue is considered an indicator of healing. But unhealthy granulation tissue is dark red, often bleeds when touched, and may indicate the presence of wound infection. The latter may need to be treated. If it doesn't heal and causes other issues with the vaginoplasty, a repair surgery may be needed such as in the case of a male who had undergone rectosigmoid neovagina surgery but who had genital granulation tissue and also stenosis (narrowing) of the introitus (opening of the canal). The patient had two surgical revisions but this didn't help. The surgeons then used pig bladder tissue to try to fix the neovagina, see
https://pubmed.ncbi.nlm.nih.gov/30413867/.
Haematoma
A form of localised bleeding, a bruise. This occures when veins or arteries are damaged (for instance, by a direct hit) and blood collects outside of the veins/arteries. This can result in a hard mass that changes colour over time as it heals. It is possible to develope a haematoma from surgery and when severe, the haematoma may require surgery to drain the blood that collected and/or control the bleeding. There is an infection risk associated with haematomas. See
https://sanaramedtech.com/blog/treating-post-surgical-seroma-hematoma/.
A female who had metoidioplasty genital surgery developed a haematoma that kept refilling that needed to be squeezed/drained. Based on her own video it seems this was a very painful and traumatic experience (see Exulansic's video 'The Artery of War'; she also had an arterial bleed).
Hair growth inside neovagina/neourethra
During genital surgery the surgeons may use skin that grows hair to create the neovagina canal or the neourethra (such as base of the penis, the scrotum, the arm or leg or abdomen, or groin). Even when the patient underwent permanent hair removal of this skin before surgery, it is possible for some hairs to still come back and grow inside the neovaginal canal or the neourethra of the phallo. It is very difficult if not impossible to remove such hairs when the surgery has already been performed. It is possible for those hairs to grow as ingrown hairs and become infected, or for the hairs to cause infections even when not ingrown. There are stories of people being able to feel hairs inside the neovaginal canal, or for hairs to come out of the phallus. Sometimes hair may not have been removed permanently from the phalloplasty donor site resulting in hair growth on the phallus and a need to shave the phallus.
Implant rupture
It is possible for implants to get a tear and break open, such as breast implants or testicular implants. This will require surgery to correct by removing the implant. Testicular implant rupture is rare, but it is conceivable for this to be less rare when done in females if their 'scrotum' is positioned further down in between the thighs/with thicker thighs.
Incontinence (urine and/or faeces)
Incontinence is the inability to retain body fluids. Urinary incontinence is the unintentional passing of urine. Faecal incontinence, or bowel incontinence is when someone struggles to control their bowels. Both conditions can result from transgender genital surgeries due to these surgeries working with urogenital tissues and with/near the intestines. These conditions are often embarrassing and upsetting and can cause people to smell of urine or poop even if they frequently bathe. It may be difficult to deal with incontinence and sometimes surgery might be required. If you have run out of surgery options for urinary incontinence, you may need to use pads and pants or a catheter for life. For bowel incontinence there are pads to wear or a plug to insert in your rectum, drugs to change your stool, or surgery to fix damage or place an electronic device to help the anus work better (for sacral nerve stimulation) or injection of bulking agents to help make the anus stronger. Sometimes a colostomy is the best solution. There are several women who have undergone transgender genital surgery who ended up with a colostomy long-term and possibly permanently. There is a male patient who underwent vaginoplasty who ended up unable to empty his bladder and with an inability to pass stool which required such a sacral nerve stimulation implant (see Exulansic's video 'The Piss Toll').
Infection
The invasion and growth of germs (bacteria, viruses, yeast, fungi) in your body. Whenever your body is cut there is a risk of infection and although a lot of measures are taken during surgery to reduce the infection risk, it is possible to end up with an infection from surgery. It is possible to get sepsis from an infection.
In 2017 a research paper was published describing a case study of an 18-year-old trans-identifying male who underwent vaginoplasty surgery resulting in a severe
E. coli infection that caused septic shock and multi-organ failure resulting in death, see
https://www.sciencedirect.com/science/article/abs/pii/S1083318816301747.
There is a story of a female who underwent a phalloplasty genital surgery who experienced a lot of complications including numerous infections: urethral infection, staph infection, MRSA infection, septic shock, and
Clostridium difficile infection. She may have had to undergo 10 surgeries as part of this effort to get a penis. She also had pulmonary embolisms and has hair growing on her phallus (see Exulansic's video 'Phalloplasty Philes: #1 Fan').
A female who underwent phalloplasty surgery developed an abscess on her arm at the site where surgeons placed a rod/tube under the skin hoping the surface of the rod would scar over so that this newly created 'tunnel' could later be used as the 'urethra' in the neophallus, see
https://onlinelibrary.wiley.com/doi/full/10.1002/cia2.12137.
Infertility / sterility
Blocking puberty and/or using cross-sex hormones can affect someone's fertility whilst taking the drugs. It is not that clear whether this kind of drug use affects long-term fertility if someone were to stop taking these drugs. Time will tell. What is clear is that when the gonads (ovaries, testes) are removed, the person is permanently sterile. This means a male will not be able to father children, and a female will not be able to mother children. If a female has her uterus removed she will not be able to carry a pregnancy using another woman's egg either. Some trans-identifying people 'bank' sperm or eggs before they start using hormones in case they want to have their own child in the future. Some people stop their hormones for some months to start producing their own sperm/eggs to then 'bank' them, before continuing their hormone use. Creating a sperm sample is very simple as it requires maturbation into a collection cup if the male is able to do so. If this is not possible, the doctor can extract sperm directly from the testes but this is a medical procedure and thus more invasive than masturbation. Females will need to undergo hormone treatment to produce multiple eggs that are then collected using a needle that goes into the body. Embryos survive better than eggs when they are frozen so some females choose to have the collected eggs fertilised with someone's sperm (either their partner's or a sperm donor). This may mean that an underage female is using a sperm donor to fertilise her eggs so she has embryos for the future, meaning that the sperm donor's sperm is used to create embryos with eggs taken from a child. More experimental medical procedures include taking some ovarian tissue and keeping it in the freezer to try to use later to create eggs.
It is important to consider that there are no guarantees with fertility methods. Especially in the case were a female no longer has her uterus (but she does still have her ovaries or she has already banked eggs or embryos), her options to become a parent may be limited as gestational surrogacy (where another woman carries a baby that is not genetically related to her as she did not provide the egg) may be illegal in some countries or it may be illegal to pay a woman for this 'service' resulting in very few women wanting to be a surrogate (this also applies to gay male relationships where by definition there is no female). Even if commercial surrogacy is available, this may not be covered by insurance and the costs may be around $50k-100k (2023 estimate).
Loss of sensation
The loss of the ability to sense with a part of your body, for instance due to nerve damage from surgery. The affected area or body part may no longer be able to feel any touch or may not feel hot/cold or may not feel pressure anymore. This may only affect a small area or might affect a larger area. If this is only a small area on your leg, this may not be such a big deal. But a small area in your genital area may encompass most of your genital so the damage may have a much larger effect on your life. Loss of sensation in your hand may be dangerous if you can no longer feel hot/cold or pressure as you might end up hurting yourself without realising it.
Necrosis
Permanent death of tissues due to a lack of blood flow to this tissue. It is possible for parts of the neovagina or neovulva to become necrotic and fall off or requiring removal. It is also possible for this to happen to part or all of the neophallus (called ‘flap failure’ or ‘flap loss’). This can also happen to tissues in the area of the phalloplasty donor site if blood flow to it has been affected such as in a reddit user who had tissue in her leg (her donor site for phalloplasty) rot.
A case is described in which a male who received what was considered a successful recto-sigmoid vaginoplasty 18 months prior experienced a life-threatening small bowel obstruction. The authors warn that it is possible to get such a life-threatening complication at any point after the surgery:
"The rate of adhesive small bowel obstruction is highest in the early period of any intra-abdominal post-operative surgeries, but the risk remains life-long. Transgender women receiving complicated vaginoplasty should be instructed to continue long-term follow-up to ensure early detection and management of post-operative complications." (see
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232285/). This suggests that after such a surgery the patient may at any point in the future need specialised urgent/emergency care. How would this knowledge affect someone's life? If patients are made aware of this risk, will they still go on backpacking holidays where they may be hours away from the nearest road? Will they be worried about any periods during which they may not have healthcare insurance and will they go into major debt if they need this surgery during such a period without insurance? Are patients even told about this life-long risk before they undergo this surgery?
Neovaginal prolapse
This is the term for when the neovaginal canal is not properly attached inside the hole in the pelvic area and partially or fully comes out of the opening in the perineum. This will require surgery to correct and may mean loss of the canal. A study published in 2014 reported that between 4-12% of males who had vaginoplasty experienced a partial or total prolapse dependent on the the technique used to attach the canal, see
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033431/.
Nerve damage
It is possible for nerves to be damage during surgery. This can result in changed sensation such as tingling, numbness, burning, loss of sensation, muscle weakness, or pain. This can resolve over time or be corrected with surgery, or may be permanent.
Pain
It is expected to experience pain after a procedure when you have maxed out your pain medication or are coming off of pain medication, and healing can hurt too. But this is expected to get better over time over a period of weeks and a couple of months. However, it is possible to keep experiencing pain or dyscomfort after surgery even months or years later.
Shape Shifter experienced intestinal cramps during sex in his colon vaginoplasty because, according to his knowledge, the colon used to create the neovaginal canal remains part of the digestive system, at least with regards to the nerves and how the brain interprets pain in that tissue. The colon is adapted to process (soft) stool as part of the digestive process, not to be touched from the inside with fingers, dilators, dildos, or a penis. He talks about his experiences undergoing several vaginoplasty surgeries and revisions on his YouTube channel.
A TikTok user who underwent metoidioplasty genital surgery still had a lot of pain 2.5 months after her surgery. Based on her video it is also clear she did not fully understand the surgical technique, underestimating how invasive the surgery was going to be and not being prepared for the amount of pain she was going to be in (see Exulansic's video 'Metoidioplasty Moments: Angry Camel Pose').
Patrick, one of the persons being interviewed as part of the 'Zembla' TV show on transgenderism, explains how years after his vaginoplasty he still experiences pain and dyscomfort in his pelvic area and bladder. He no longer identifies as a transwoman and instead now sees himself as a gay male. He no longer has male genitalia so he feels like his life is ruined by the medical interventions he underwent as part of his gender transition.
Pregnancy whilst on testosterone
Testosterone is a teratogen meaning that it can cause birth defects when a pregnant female uses the drug. In sheep, exposure to testosterone affected development of female foetuses (see
https://academic.oup.com/endo/article/146/7/3185/2500473). In mice, testosterone affected development of the genitals in female foetuses (see
https://www.pnas.org/doi/full/10.1073/pnas.1610471113).
There are suggestions that prenatal and neonatal testosterone exposure may affect human behaviour (see
https://pubmed.ncbi.nlm.nih.gov/17084045/; for a study on monkeys, see
https://www.sciencedirect.com/science/article/abs/pii/S0018506X09000658).
Replacement of erectile device/implant
Erectile implants are developed for males who have a penis but suffer from erectile dysfunction. These devices/implants are estimated to have a life expectancy of 5 to 20 years . This data will come from male patients, possibly older on average than the females who opt for phalloplasty with an erectile implant. It is also conceivable that male patients are less active with the implant if they are on average of older age than the females who get this, so it is conceivable that the implant will last less long as it is used more. Moreover, the neophallus is not a penis so possibly higher risks of erosion may limit the lifespan of the implant in females. If you get the implant at age 20 or 30 and you may need to get it replaced every 10 years, this means 3-5 more surgeries later in life, possibly a lot more if you wear out the device faster.
Revision surgery
If the initial surgery did not leave you with the aesthetics you wanted and/or there are functional issues with your surgery results, you may want/need a revision surgery. Another surgery means another general anaesthesia and another situation in which you are taking risks. Moreover, there is no guarantee that whatever the issue is that makes you choose/need a revision will be solved for good.
Sepsis
Septicaemia, blood poisoning. A life-threatening reaction to an infection resulting in damage to your tissues and organs. This needs treatment in the hospital immediately.
A male who underwent vaginoplasty surgery and then revision surgery for it, and some month later got larger breast implants (he already had implants before) was found grey, cold and unresponsive by his boyfriend. His implants were very infected causing a kidney infection and then sepsis and kidney failure causing him to 'nearly die'. He got a secondary infection in his chest too. If he had been found any later, he may very well have died (see Exulansic's videos 'Vaginoplasty Volumes: Through the Eye of the Needle' and 'Get well soon, Ruby Fiera!').
Seroma
A seroma is a sterile collection of fluid under the skin, usually at the surgery site. The body may do this to fill up space after tisse has been removed. When a seroma is large or causes pain, it may need to be drained by needle and syringe and a drain may be put in. It is possible for a seroma to come back and to need to get it drained multiple times. A seroma may become infected or turn into an abscess. See
https://sanaramedtech.com/blog/treating-post-surgical-seroma-hematoma/.
Sexual dysfuction
Surgery to the genitals may affect sexual function. A study on males who had undergone robotic peritoneal flap vaginoplasty showed that of those who had this surgery at least one year before the study was conducted, 14% were not able to experience orgasm, this was not correlated with orgasmic ability before surgery but was negatively related to smoking history, see
https://pubmed.ncbi.nlm.nih.gov/35337785/. A 2018 study that included males who had undergone penile inversion vaginoplasty found that 26% were unsatisfied or highly unsatisfied with neoclitoral sensitivity and that a 33% were unsatisfied or highly unsatisfied with neovaginal depth and 10% of patients did not experience orgasm, see
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5994261/. A meta analysis (reviewing many studies who report on patient outcomes) showed that the ability to achieve orgasm was 76% in patients who had undergone vaginoplasty surgery meaning that 24% of those patients were not able to experience orgasm. This low average was mostly due to penile inversion vaginoplasty, the most common form of vaginoplasty, with 73% being able to have an orgasm. The patients who underwent a form of intestinal vaginoplasty had better results with 95% being able to achieve orgasm. The patients who underwent intestinal vaginoplasty had a higher proportion of fistula, stenosis and strictures, and prolapse than the males who underwent penile inversion (see
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7984836/). From this study it is not clear whether the studies they included managed to follow up on all the patients on who they performed this surgery.
Then there's the story of Jazz Jennings who after puberty blockers and cross sex hormones had a botched vaginoplasty surgery (because he did not have enough genital skin to work with due to his puberty being blocked; he needed multiple revisions and the surgeons ended up taking skin grafts from his upper thigh area). Jazz seems to be struggling with sexual funtion. Trans-identifying male surgeon Marci Bowers was involved in some of Jazz' vaginoplasty surgeries and is reported as having stated that if a someone has never experienced orgasm before surgery and their puberty has been blocked, it is very difficult to achieve that afterwards. He acknowledges this is an overlooked problem and he wonders how this will affect the patient's long-term happiness if they are not able to be a responsive lover (see
https://www.psychologytoday.com/gb/blog/women-who-stray/202111/does-affirmative-treatment-impair-sexual-response-in-trans-youth).
A story of a female reddit user who underwent metoidioplasty genital surgery describes how at four months after the surgery she is still struggling with sensations in her genital area. She can only feel half of her micro "penis" and the sensation she does have she describes as 'half pleasurable and half just uncomfortable' (see Exulansic's video 'Metoidioplasty Moments: The Piss Nick').
Oestrogen use by males is associated with a decreased libido and can cause erectile dysfunction. This can result in the penis shrinking. The testicles are also expected to shrink. Vaginoplasty may rely on the penile and scrotum skin to create a 'convincing' neovulva and neovagina so shrinking of this 'source' material may pose issues when the patient wants to undergo vaginoplasty.
Testosterone use by females can cause vaginal atrophy (thinning and drying of the vaginal tissue making it more fragile) and pain during sexual intercourse.
See the following paper for a discussion of affirmation-only treatment for transgenderism and the role of the placebo effect (including a discussion on sexual function):
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9886596/.
Stenosis, stricture
A narrowing of a structure. It is possible to have stenosis in the neovagina canal making it painful and/or difficult or even impossible to dilate and have sexual intercourse. This can make it difficult to clean the inside (douching) which may result in unpleasant smell or infections.
Shape Shifter is a male who has medically transitioned but regrets his genital surgeries. He developed stenosis of the canal almost immediately after surgery. Three revision surgeries to help correct the stenosis resulted in him developing a colorectal fistula. This fistula was torn back open during his fourth revision surgery and no surgeon will help him now as they suspect that another revision surgery may leave Shape with a colostomy bag, see
https://reduxx.info/opinion-the-boy-who-shifted-shapes/ (and see Exulansic's video 'Vaginoplasty Volumes: The WPATH of Least Dehiscence' and the videos in which Exulansic and Shape Shifter interview each other).
Another male who underwent vaginoplasty experienced vaginal stenosis, requiring the canal to be replaced in an additional surgery, 8 months after the initial surgery (see Exulansic's video 'Update on Rumer Has a Clit Dude').
It is also possible for a (neo)urethra made as part of a metoidioplasty or phalloplasty to become too narrow. This restricts the flow of urine and may cause diverticuli and infections such as urinary tract infection. Stenosis or stricture may make it impossible to fully empty the bladder which might make the patient not drink enough water because they have such difficulty passing urine, which can in turn cause kidney stones or bladder stones. This also increases the chances of getting a urinary tract infection (UTI).
Stroke
An ischaemic stroke is what occurs when the blood flow to part of the brain is cut off. This can be due to a blood clot or air bubble (embolism) blocking the flow of blood. A hemorrhagic stroke is when an artery in the brain ruptures or leaks putting pressure on the brain which damages the brain cells. A mini-stroke (a transient ischemic attack) blocks blood flow only for a short time (less than 5 minutes). It is possible for a stroke to be a surgical complication.
A 30-year old male experienced a stroke during facial feminisation surgery. His complaints were ignored by hospital staff and when he eventually did get appropriate medical care elsewhere (emergency services), he had lost the ability to use one of his arms, from which he never recovered so he now has a permanent disability. It turns out that during his facial feminisation surgery they severely damaged his carotid artery and that as a result he had suffered a stroke in his right frontal lobe resulting in brain damage (see his reddit post titled 'I thought FFS would change my life, but not like this... (Dr. Alex Kim)' and Exulansic's video 'Facial Feminization Fumbles: A Sense of Humerus').
Suicidality
Despite activists claiming that gender transition is the only way to prevent transgender people from wanting to exit this world, there are people who after medical transition remain/become suicidal. Patrick, a Dutch man, is one of these people. He is interviewed in the 'Zembla' documentary on transgenderism in which he shares his lifelong struggles with severe mental health issues and substance abuse. He was failed by the medical system who on his first attempt to get help for transgenderism recognised he was not transgender, but when he tried again at another clinic some years later he, in his experience, was affirmed and encouraged to medically transition. He underwent vaginoplasty surgery that he now deeply regrets. He now no longer identifies as a transwoman but as a homosexual man. He no longer has male genitalia and he experiences dyscomfort in his pelvic area and his bladder and he is struggling with severe mental health issues to the point where he is contemplating assisted suicide, for which he has been approved (in the Netherlands, assisted suicide is allowed in certain circumstances).
Some scientific data suggests gender-affirming treatment may reduce suicide-related outcomes (see
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10027312/ for a narrative review), but some of these studies suffer from issues such as no data on suicidality before treatment, not controlling for other mental health issues, or loss to follow up (not being able to contact every person that underwent gender-affirming treatment in your clinic; it is possible that the proportion of people with regret, a bad outcome, or the worst outcome: suicide, is higher in those patients the clinic is unable to contact). These studies usually only look at people who received affirmation treatment (drugs and surgeries) and do not compare the outcomes for this group to a group with the same diagnosis who get no treatment or who get another kind of treatment (such as talk therapy or any other kind of therapy/treatment for mental health). It is then not possible to say which kind of treatment is superior when it comes to reducing suicidality (or compare any other kind of outcome).
Testosterone gel transfer
One method for taking the drug testosterone is by a gel that is applied onto the skin. The testosterone will be absorbed from the gel into the skin. One practical problem with this is that it is possible for others around the patient to be exposed to this testosterone by touching the patient's skin where the gel was applied or possibly through sharing a towel or bedding on which the gel is rubbed off. This testosterone exposure can be harmful to children of both sexes and to women. A case in the literature describes a 31 year old woman who had grown more body hair in the past year. Her testosterone level was measured as being 6.7 nmol/l at the highest when less than 2.5 nmol/l is considered normal. Her partner used testosterone gel for a medical condition but he was not aware of the recommendation to take a shower or cover the area where he applied the gel before having physical contact with others. When he stopped using the gel, her testosterone level went back to normal. When he started using the gel again, despite explicit instructions to cover the application site or shower before contact, the woman's testosterone level increased again. The male then switched to injecting testosterone and the woman's testosterone went back to normal (see
https://academic.oup.com/humrep/article/24/2/425/808493). This illustrates that apparently instructions were not given or followed, and that even after the partner was exposed to testosterone and explicit instructions to reduce transfer, the female partner was still exposed to testosterone.
A publication describes two cases of transfer of testosterone gel from fathers (males using this gel for medical reasons) to their children. The first case involves a two year old boy whose penis had grown, who was experiencing frequent erections, who was growing pubic hair, and who had grown taller in the past few months. The penis was at Tanner class (stage) III which is usually seen in boys around age 13. He had a very high level of testosterone for his age and his bone age had advanced by three years. The changes seemingly reversed once he was no longer exposed to testosterone gel. The second case involved a 6 year old boy who had started growing pubic hair and growth of the penis in the past few months. He was also tall and had advanced bone age. His exposure was suppressed but he nevertheless started puberty. Read about both cases here:
https://www.elsevier.es/en-revista-endocrinologia-diabetes-nutricion-english-ed--413-articulo-potential-consequences-in-children-testosterone-S2530018017300768.
The UK government includes information on this topic on its website stating a risk of harm to children following accidental exposure to Testogel (a testosterone gel). They warn of premature puberty and genital enlargement in children who were in close physical contact with an adult using testosterone gel and who were repeatedly exposed (see
https://www.gov.uk/drug-safety-update/topical-testosterone-testogel-risk-of-harm-to-children-following-accidental-exposure).
Urination / voiding issues
It is possible to severely damage the ability to urinate with gender genital surgeries. There is the story of a male who got vaginoplasty surgery and now has to use the bathroom to pee every one or two hours including when he wants to sleep (see Exulansic's video 'Jacob's Bladder'). There are also the stories of many females who had gender genital surgery who ended up with urination difficulties such as Gruffin (covered extensively by Exulansic) who developed bladder stones (in addition to nearly losing a leg and nearly dying from blood clots). Many females who get phalloplasty appear to struggle to complete urination and after peeing always have some urine dribble out of the phallus no matter how much they squeeze and push and jump and wiggle.
UTI
UTI stands for urinary tract infection. It encompasses infections of any part of the urinary system: the kidneys, ureters, bladder, and urethra. If someone struggles to urinate or can not fully void their bladder they might be at a higher risk of developing a UTI. This may start in the urethra and if not successfully treated can develop into a bladder infection or even a kidney infection.
Vocal damage
It is possible for males who get so-called vocal feminisation surgery to end up with damage to their voice losing part of their vocal range and for their voice to seemingly stop working as described by one such patient posting on reddit (see Exulansic's video 'Tracheal Troubles: Falsetto Hope').
Wound dehiscence / wound separation
This is the term for when a surgery incision reopens. This can be the result of an infection, pressure on the sutures, poor suture technique, or decreased blood flow. This may require medical attention to resolve. This is seen in some people who undergo gender genital surgeries and wound separation can increase the risk for infection, can cause more scarring, and can change what the end result looks like.
One such example of a patient with wound separation is Rylan who chose to undergo a cosmetic double mastectomy for gender reasons. Because of her obesity she had few surgeons to choose from (surgery is more risky on obese people so most surgeons will have a BMI cap for (cosmetic) surgeries). The surgeon that removed her healthy breasts neglected her concerns about issues with healing and wound separation despite frequent communication from Rylan to the surgical team. Rylan had to find emergency medical care elsewhere when she had a golfball-sized blood clot fall out of her wound whilst out in public. By this time she had been bleeding from the wounds for days. She then had to undergo another surgery to have over half a foot of flesh that had become infected with a bacterial infection removed. One of her nurses told her she could have gone septic had she not gotten this 'repair' surgery. You can read all about the surgeon who removed Rylan's healthy breasts here:
https://lilymaynard.com/wielding-the-sidhbh-gallagher/, and view video content about this case in Ella Androphobia's video titled 'Dr. Sidhbh Gallagher - Necrotizing Gaslighter'.